HIV/AIDS

California man appears to be another person cured of HIV after a stem cell transplant

Herman Nnyanzi Send an email
126 1,617

A man in southern California, dubbed the ‘City of Hope patient’, appears to be the latest person cured of HIV after receiving a stem cell transplant from a donor with a rare mutation, bringing the total to five, according to a presentation on Monday at the 24th International AIDS Conference (AIDS 2022) in Montreal.

The man remains free of HIV more than 17 months after stopping antiretroviral therapy (ART) and his leukaemia also remains in remission.

The man is older than the handful of other people previously cured after such a procedure, he has been living with HIV longer and he received a less harsh conditioning regimen prior to the transplant.

This suggests that this approach may be possible for a wider subset of HIV-positive people with advanced cancer, but it is far from feasible for the vast majority of people living with HIV.

Yet the case could provide clues that help researchers develop more widely applicable approaches for long-term HIV remission.

“The City of Hope patient’s case, if the right donor can be identified, may open up the opportunity for more older patients living with HIV and blood cancers to receive a stem cell transplant and go into remission for both diseases,” said Dr Jana Dickter of the City of Hope cancer centre near Los Angeles, who described the case at the conference and at an advance media briefing last week.

The City of Hope patient

The latest case involves a 66-year-old white man who was diagnosed with HIV in 1988. At one point, his CD4 count fell so low (below 100) that he was diagnosed with AIDS.

He started ART when it became available in the mid-1990s. In 2018, he was diagnosed with acute myelogenous leukaemia.

Complete cure or long-term remission?

Researchers are still working to learn why these cures after stem cell transplantation were successful while other attempts have failed. Using stem cells with a double CCR5-delta-32 mutation seems to be key.

At CROI 2012, researchers described two HIV-positive men in Boston who received stem cell transplants for cancer treatment from donors without the mutation. Both experienced viral rebound after stopping ART, though this was delayed.

Some have posited that the graft-versus-host reaction might play a role in eradicating HIV, but the five patients who were cured received different pre-transplant conditioning regimens and some experienced mild or no graft-versus-host disease.

Even as each new case provides more answers, stem cell transplants remain far too risky for people who do not need them to treat life-threatening cancer.

Seeing the host as ‘foreign’, the donor immune cells can attack the recipient’s tissues and organs, which may necessitate immunosuppressive therapy.

While waiting for donor cells to engraft, patients are highly susceptible to infections. What’s more, the procedure is medically intensive and costly and would be impossible to scale up to treat the millions of people living with HIV worldwide.

Nonetheless, each case offers clues that could help researchers develop strategies that lead to more widely applicable functional cures, or long-term remission without ART. Deeks, for example, hopes emerging gene-editing technologies might be used to delete or disable CCR5 receptors and make an individual’s own immune cells resistant to HIV entry.

“These cases are still interesting, still inspiring and illuminate the search for a cure,” International AIDS Society president-elect Dr Sharon Lewin of the Peter Doherty Institute for Infection and Immunity in Melbourne told reporters during an AIDS 2022 advance media briefing.

But some advocates question why these rare cures, which won’t help most people living with HIV, get so much more attention than natural or post-treatment controllers, one of whom was also described at the conference.

“I think they’re selling us a bill of goods,” DARE-CAB member Michael Louella said during the discussion following the presentation.

“I’m never going to get that [a stem cell transplant], but this other type of remission that doesn’t get so much attention could be applicable for more people.”

Tags
Herman Nnyanzi Send an email
126 1,617

Herman Nnyanzi

126 Comments

  6. Great write-up, I am normal visitor of one’s web site, maintain up the excellent operate, and It is going to be a regular visitor for a lengthy time.

  8. What’s Happening i am new to this, I stumbled upon this I’ve found It positively useful and it has aided me out loads. I hope to contribute & aid other users like its helped me. Great job.

  9. Nearly all of what you assert is supprisingly precise and that makes me ponder the reason why I hadn’t looked at this with this light previously. This particular piece really did turn the light on for me as far as this subject goes. Nevertheless there is one factor I am not really too cozy with so whilst I attempt to reconcile that with the actual main idea of your point, allow me see just what all the rest of the visitors have to say.Well done.

  10. I truly appreciate this post. I have been looking all over for this! Thank goodness I found it on Bing. You’ve made my day! Thank you again

  16. Woah! I’m really digging the template/theme of this site. It’s simple, yet effective. A lot of times it’s very hard to get that “perfect balance” between usability and appearance. I must say you’ve done a awesome job with this. Also, the blog loads very quick for me on Opera. Outstanding Blog!

  20. Valuable information. Lucky me I found your website by accident, and I’m shocked why this accident did not happened earlier! I bookmarked it.

  22. Your style is so unique compared to many other people. Thank you for publishing when you have the opportunity,Guess I will just make this bookmarked.2

  23. What Is ProDentim? ProDentim is a teeth health supplement developed to repopulate the mouth with good bacteria and improve overall dental health.

  24. What Is Sumatra Slim Belly Tonic? Sumatra Slim Belly Tonic is a weight loss supplement that targets the root cause of weight gain issues.

  26. I not to mention my guys came going through the nice helpful tips on your web page then suddenly got a horrible feeling I never thanked the blog owner for those tips. The guys were definitely consequently very interested to read them and now have sincerely been taking advantage of them. Thanks for turning out to be simply kind as well as for obtaining certain magnificent tips most people are really desperate to be aware of. Our honest regret for not expressing gratitude to you sooner.

  27. Wonderful beat ! I would like to apprentice while you amend your site, how could i subscribe for a blog website? The account aided me a acceptable deal. I had been tiny bit acquainted of this your broadcast provided bright clear idea

  35. Please let me know if you’re looking for a article author for your weblog. You have some really good posts and I believe I would be a good asset. If you ever want to take some of the load off, I’d love to write some material for your blog in exchange for a link back to mine. Please blast me an e-mail if interested. Thanks!

  36. I needed to compose you a very little observation in order to give many thanks yet again with your superb tricks you have contributed above. It’s really strangely open-handed with people like you to grant without restraint just what a few people could have sold as an e-book to end up making some profit for their own end, and in particular considering the fact that you could have tried it if you ever considered necessary. These secrets in addition worked to be a good way to be certain that other individuals have the same zeal just like my own to figure out whole lot more in respect of this problem. Certainly there are some more pleasant situations in the future for individuals that examine your site. fitspresso reviews

  37. What is Renew? Renew is a dietary supplement designed to support blood flow while also aiming to boost testosterone levels and provide an explosive energy drive

  42. I’m not that much of a internet reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your website to come back later on. Cheers

  44. What¦s Going down i am new to this, I stumbled upon this I’ve found It positively helpful and it has helped me out loads. I’m hoping to give a contribution & assist different customers like its helped me. Good job.

  45. I’ve been exploring for a little for any high quality articles or blog posts on this kind of area . Exploring in Yahoo I at last stumbled upon this site. Reading this information So i’m happy to convey that I have a very good uncanny feeling I discovered just what I needed. I most certainly will make sure to do not forget this site and give it a glance regularly.

  46. Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me. Anyways, I’m definitely happy I found it and I’ll be book-marking and checking back frequently!

  47. Good day! I know this is somewhat off topic but I was wondering if you knew where I could find a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  49. Good ?V I should certainly pronounce, impressed with your website. I had no trouble navigating through all tabs and related info ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, site theme . a tones way for your customer to communicate. Excellent task..

  51. Hey there! Someone in my Myspace group shared this website with us so I came to check it out. I’m definitely loving the information. I’m book-marking and will be tweeting this to my followers! Outstanding blog and outstanding design and style.

  52. I like what you guys are up also. Such clever work and reporting! Keep up the excellent works guys I have incorporated you guys to my blogroll. I think it’ll improve the value of my web site 🙂

  54. Woah! I’m really enjoying the template/theme of this website. It’s simple, yet effective. A lot of times it’s challenging to get that “perfect balance” between superb usability and visual appearance. I must say you’ve done a excellent job with this. Additionally, the blog loads very quick for me on Internet explorer. Outstanding Blog!

  57. I’ve been browsing on-line more than 3 hours today, yet I by no means found any attention-grabbing article like yours. It?¦s pretty worth sufficient for me. In my view, if all web owners and bloggers made just right content as you probably did, the web can be much more helpful than ever before.

  58. Nice post. I learn something more challenging on different blogs everyday. It will always be stimulating to read content from other writers and practice a little something from their store. I’d prefer to use some with the content on my blog whether you don’t mind. Natually I’ll give you a link on your web blog. Thanks for sharing.

  59. Nice post. I learn something more challenging on different blogs everyday. It’ll all the time be stimulating to learn content from other writers and follow a little something from their store. I’d want to make use of some with the content material on my weblog whether you don’t mind. Natually I’ll offer you a link on your internet blog. Thanks for sharing.

  60. Just want to say your article is as surprising. The clarity to your post is just spectacular and that i can suppose you’re knowledgeable on this subject. Well with your permission let me to snatch your feed to stay updated with drawing close post. Thank you one million and please continue the enjoyable work.

  61. Attractive section of content. I just stumbled upon your website and in accession capital to assert that I get actually enjoyed account your blog posts. Anyway I’ll be subscribing to your feeds and even I achievement you access consistently rapidly.

  62. you’re truly a excellent webmaster. The website loading speed is incredible. It seems that you’re doing any unique trick. Moreover, The contents are masterpiece. you’ve done a fantastic activity on this topic!

  64. Wonderful website. Lots of useful info here. I am sending it to a few pals ans also sharing in delicious. And obviously, thanks to your effort!

  65. Heya just wanted to give you a brief heads up and let you know a few of thepictures aren’t loading properly I’m not sure why butI think its a linking issue I’ve tried it in two different internet browsers and both show the same results

  66. Nice post. I was checking constantly this weblog and I am impressed! Extremely helpful information particularly the remaining part 🙂 I care for such info a lot. I was seeking this particular information for a very lengthy time. Thanks and good luck.

  68. What i do not realize is in truth how you are now not actually a lot more neatly-favored than you may be right now. You’re very intelligent. You understand therefore significantly in the case of this subject, produced me in my opinion believe it from so many numerous angles. Its like women and men are not involved until it is one thing to do with Girl gaga! Your personal stuffs nice. Always maintain it up!

  69. excellent publish, very informative. I ponder why the opposite experts of this sector don’t notice this. You should continue your writing. I’m sure, you’ve a huge readers’ base already!

  70. Thanx for the effort, keep up the good work Great work, I am going to start a small Blog Engine course work using your site I hope you enjoy blogging with the popular BlogEngine.net.Thethoughts you express are really awesome. Hope you will right some more posts.

  72. Hey There. I found your blog using msn. This is a really well written article. I will make sure to bookmark it and come back to read more of your useful info. Thanks for the post. I will definitely comeback.

  73. Have you ever considered publishing an ebook or guest authoring on other sites? I have a blog based upon on the same ideas you discuss and would really like to have you share some stories/information. I know my visitors would appreciate your work. If you are even remotely interested, feel free to shoot me an email.

  74. My spouse and I absolutely love your blog and find nearly all of your post’s to be exactly what I’m looking for. Would you offer guest writers to write content available for you? I wouldn’t mind writing a post or elaborating on most of the subjects you write about here. Again, awesome weblog!

  75. Hi there! This post could not be written any better! Reading through this post reminds me of my old room mate! He always kept chatting about this. I will forward this page to him. Pretty sure he will have a good read. Thanks for sharing!

  76. Very good written story. It will be valuable to anybody who utilizes it, including yours truly :). Keep up the good work – i will definitely read more posts.

  77. I discovered your weblog site on google and examine a couple of of your early posts. Proceed to keep up the very good operate. I simply additional up your RSS feed to my MSN News Reader. Looking for forward to reading extra from you later on!…

  78. I think this is one of the most significant information for me. And i am glad reading your article. But want to remark on some general things, The website style is ideal, the articles is really great : D. Good job, cheers

  79. Its such as you read my mind! You appear to understand a
    lot about this, such as you wrote the book in it or something.

    I feel that you simply could do with a few % to force
    the message house a bit, however instead of that,
    that is fantastic blog. A fantastic read. I will certainly be back.

    Also visit my website :: provadent.com phone number

  81. I have been browsing online greater than 3 hours these days, but I never
    found any attention-grabbing article like yours.

    It’s beautiful worth sufficient for me. Personally, if all website owners and bloggers made excellent content material
    as you probably did, the net might be a lot more useful than ever before.

    Here is my web page fitspresso

  84. Today, I went to the beach with my children. I found a sea shell and gave it to my 4 year old daughter and
    said “You can hear the ocean if you put this to your ear.”
    She placed the shell to her ear and screamed. There was a
    hermit crab inside and it pinched her ear. She never wants to
    go back! LoL I know this is completely off topic but I had to tell someone!

    Here is my web page :: tonic greens

  89. Hey would you mind letting me know which web host you’re
    working with? I’ve loaded your blog in 3 different web browsers and I must say this blog
    loads a lot quicker then most. Can you suggest a
    good hosting provider at a honest price? Cheers, I
    appreciate it!

    Take a look at my web site – provadent soft tablets

  91. Greetings from Florida! I’m bored to death at work so I decided
    to check out your website on my iphone during lunch break.
    I love the information you provide here and can’t wait to take a look when I get home.

    I’m shocked at how fast your blog loaded on my phone ..
    I’m not even using WIFI, just 3G .. Anyways,
    very good site!

    Stop by my homepage :: billionaire brain wave review

  93. I’m not sure where you’re getting your info, but
    great topic. I needs to spend some time learning much more or understanding more.
    Thanks for wonderful information I was looking for
    this information for my mission.

    my page dentavim hoax

  96. I was curious if you ever thought of changing the page layout of
    your site? Its very well written; I love what youve got to
    say. But maybe you could a little more in the way of content
    so people could connect with it better. Youve got an awful lot of text for only having
    1 or 2 pictures. Maybe you could space it out better?

    My blog post lung clear pro review

  97. After I originally left a comment I appear to have clicked the -Notify me when new comments are added- checkbox and now whenever a comment
    is added I get four emails with the exact same comment. Is there a means you are able to remove me from that service?
    Appreciate it!

    Here is my web-site :: testoprime review

  98. I do not know whether it’s just me or if perhaps everyone else encountering problems with your blog.
    It appears as though some of the text within your content are running off the screen. Can someone else please comment and let me know if this is happening to them as well?
    This may be a problem with my web browser because I’ve had this happen previously.
    Appreciate it

    Have a look at my webpage :: fitspresso fda

  104. Great article! This is the type of info that are supposed to be shared around the web.
    Shame on the seek engines for not positioning this publish upper!
    Come on over and seek advice from my site . Thank you =)

    Take a look at my web page: testoprime india

  112. Hi, i believe that i noticed you visited my web site thus i got here to go back the choose?.I’m trying to in finding things to improve my site!I assume its good enough to make use of a few of your ideas!!

    Take a look at my web page :: item643629683

  114. Hey there just wanted to give you a quick heads up. The words in your post seem
    to be running off the screen in Firefox. I’m not sure if this is a formatting
    issue or something to do with internet browser compatibility but I figured I’d post to let you know.

    The layout look great though! Hope you get the issue fixed soon. Many
    thanks

    my webpage lung clear pro

  119. Awesome website you have here but I was curious about if
    you knew of any discussion boards that cover the same topics discussed here?

    I’d really like to be a part of community where I can get opinions from other knowledgeable people that share the same interest.
    If you have any suggestions, please let me know. Cheers!

    My blog post :: what is the growth matrix

Leave a Reply